Antiulcerogenic Activity of Some Sesquiterpene Lactones Isolated from Artemisia annua

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Antiulcerogenic activity of some sesquiterpene lactones isolated from Artemisia annua.

Artemisinin 1, dihydro-epideoxyarteannuin B 2 and deoxyartemisinin 3 were isolated from the sequiterpene lactone-enriched fraction obtained from the crude ethanolic extract of Artemisia annua L. These compounds were tested on ethanol and indomethacin-induced ulcer models. Compound 1 did not afford cytoprotection under the experimental models tested. Only compounds 2 and 3 decreased the ulcerati...

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Artemisia annua L.: evidence of sesquiterpene lactones’ fraction antinociceptive activity

BACKGROUND Artemisia annua L. has been used for many centuries in Chinese traditional medicine. Artemisinin, the active principle was first isolated and identified in the 1970s becoming the global back bone to the fight against malaria. Our research group previously developed an economic and ecological friendly process to obtain this compound. In the pursuit to also exploit the residue generate...

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Biotechnology approaches for production of antiulcerogenic dihydro-epideoxyarteannuin B isolated from Artemisia annua L

Methodologies were developed for the establishment and cultivation of Artemisia annua L (CPQBA 2/39 x PL5 hybrid) roots submitted to light conditions and genetic transformation performed with Agrobacterium rhizogenes (15834 and 8196 strains). The transgenic and nontransgenic (normal) roots were cultured in Murashige and Skoog (1962) medium, kept under different photoperiodic conditions and anal...

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Sesquiterpene Lactones from Achillea

The species of genus Achillea, particularly those belonging to the Achillea millefolium group have received a lot of attention so far, due to their use in traditional medicine. Among the numerous chemical compounds isolated from the A. millefolium species, the sesquiterpene lactones are usually one of the major constituents (Seaman, 1982). Continuing our chemotaxonomic examination of Bulgarian ...

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Crystal structure of a bioactive sesquiterpene isolated from Artemisia reticulata

The title compound, C15H24O2 {systematic name: 1-[6-hy-droxy-7-(propan-2-yl)-4-methyl-idene-2,3,3a,4,5,6,7,7a-octa-hydro-1H-inden-1-yl]ethanone} was iso-la-ted from A. reticulata by column chromatography over silica gel by gradient solvent elution. The mol-ecule comprises a bi-cyclo-[4.3.0]nonane ring bearing acet-oxy, hy-droxy and isopropyl substituents, and an exocyclic double bond on the cyc...

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ژورنال

عنوان ژورنال: Planta Medica

سال: 2002

ISSN: 0032-0943,1439-0221

DOI: 10.1055/s-2002-32570